Short-course zidovudine reduces perinatal HIV transmission

Perinatal HIV Prevention Trial (PHPT-1) Research Protocol Title: A SHORT ZIDOVUDINE (ZDV) COURSE TO PREVENT PERINATAL HIV IN THAILAND

Effect of perinatal short-course zidovudine on the clinical and virological manifestations of HIV-1 subtype E infection in infants.

BACKGROUND The perinatal short-course zidovudine (ZDV) chemoprophylaxis that can reduce HIV-1 vertical transmission by 51% has been widely practiced in developing countries such as Thailand because of its simpler and less cost. OBJECTIVES To investigate the effects of short-course regimen of oral ZDV for prophylaxis of HIV-1 subtype E vertical transmission among 'break-through' HIV-1 infected...

Breast milk HIV-1 suppression and decreased transmission: a randomized trial comparing HIVNET 012 nevirapine versus short-course zidovudine.

OBJECTIVE To compare the effect of perinatal regimens of short-course nevirapine (HIVNET 012) and zidovudine [Thai-Centers for Disease Control and Prevention (CDC) regimen] on breast milk viral shedding and perinatal transmission during the first 6 weeks postpartum in a randomized clinical trial. DESIGN Randomized clinical trial. METHODS Pregnant HIV-1 seropositive women in Nairobi, Kenya w...

Epidemiology of Perinatal HIV Transmission

200 According to UNAIDS, a joint United Nations program on HIV/AIDS, there are approximately 19.2 million women living with HIV or AIDS, accounting for nearly half of all infections worldwide. Similarly, an estimated 3.2 million children under the age of 15 are living with HIV or AIDS, the overwhelming majority of whom acquired HIV through perinatal transmission and live in Sub-Saharan Africa. ...

Efficacy of antenatal zidovudine in reducing perinatal transmission of human immunodeficiency virus type 1. The New York City Perinatal HIV Transmission Collaborative Study Group.

New York City women (321) enrolled during 1986-1993 in an observational cohort study were analyzed retrospectively to determine the effectiveness of antenatal zidovudine in reducing perinatal transmission of human immunodeficiency virus type 1 (HIV-1) in women with various CD4+ lymphocyte counts (< 200, 200-499, > 499/microL). When CD4+ lymphocyte level was controlled for, women prescribed zido...